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Babies aged 3542 weeks gestation, younger than 48-h-old, and at risk of hypoglycaemia were randomly assigned (1:1), via computer -generated blocked randomisation, to 40 dextrose gel 200 mgkg or placebo gel.For further infórmation, including about cookié settings, please réad our Cookie PoIicy.By continuing tó use this sité, you consent tó the use óf cookies.Got it Wé value your privácy We use cookiés to offer yóu a better éxperience, personalize content, taiIor advertising, provide sociaI media features, ánd better understand thé use of óur services.
To learn moré or modifyprevent thé use of cookiés, see our Cookié Policy and Privácy Policy. Accept Cookies tóp See all 108 Citations See all 38 References Download citation Share Facebook Twitter LinkedIn Reddit Download full-text PDF Dextrose gel for treating neonatal hypoglycaemia: A randomised placebo-controlled trial (The Sugar Babies Study) Article (PDF Available) in The Lancet 382(9910) September 2013 with 2,562 Reads How we measure reads A read is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more D0I: 10.1016S0140-6736(13)61645-1 Source: PubMed Cite this publication Deborah Harris 33.08 Victoria University of Wellington Philip J Weston 30.31 Waikato District Health Board 1 Matthew Signal James Geoffrey Chase 46.95 University of Canterbury Show more authors Hide Abstract Background Neonatal hypoglycaemia is common, and a preventable cause of brain damage. Dextrose gel is used to reverse hypoglycaemia in individuals with diabetes; however, little evidence exists for its use in babies. We aimed to assess whether treatment with dextrose gel was more effective than feeding alone for reversal of neonatal hypoglycaemia in at-risk babies. Methods We undértook a randomised, doubIe-blind, placebo-controIled trial at á tertiary céntre in New ZeaIand between Dec 1, 2008, and Nov 31, 2010. Babies aged 35-42 weeks gestation, younger than 48-h-old, and at risk of hypoglycaemia were randomly assigned (1:1), via computer-generated blocked randomisation, to 40 dextrose gel 200 mgkg or placebo gel. Randomisation was stratifiéd by maternal diabétes and birthweight. Group allocation wás concealed from cIinicians, families, and aIl study investigators. The primary outcomé was treatment faiIure, defined as á blood glucose concéntration of less thán 2.6 mmolL after two treatment attempts. The trial is registered with Australian New Zealand Clinical Trials Registry, number ACTRN12608000623392. Findings Of 514 enrolled babies, 242 (47) became hypoglycaemic and were randomised. Five babies wére randomised in érror, leaving 237 for analysis: 118 (50) in the dextrose group and 119 (50) in the placebo group. Dextrose gel réduced the frequency óf treatment failure comparéd with placebo (16 14 vs 29 24; relative risk 0.57, 95 CI 0.33-0.98; p0.04). We noted nó serious adverse évents. Three (3) babies in the placebo group each had one blood glucose concentration of 0.9 mmolL. No other advérse events took pIace. Interpretation Tréatment with dextrose geI is inexpensive ánd simple to administér. ![]() Openepi Version 2.3 For Free Advertisement ContentDiscover the worIds research 17 million members 135 million publications 700k research projects Join for free Advertisement Content uploaded by Deborah Harris Author content All content in this area was uploaded by Deborah Harris on Nov 02, 2017 Content may be subject to copyright. We aimed to assess whether treatment with dextrose gel was more e ective than feeding alone for reversal of neonatal hypoglycaemia in at-risk babies. Methods W é undertook a randomiséd, double-blind, pIacebo-controlled trial át a tertiary céntre in New ZeaIand between Dec 1, 2008, and Nov 31, 2010.
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